Ketamine Assisted Therapy
What is Ketamine Assisted Therapy?
Ketamine-assisted therapy is an emerging, evidence-based approach that blends the rapid-acting biochemical effects of ketamine with the long-term benefits of psychotherapy. By creating a temporary altered state of consciousness, it helps clients explore emotional issues from a new perspective and accelerate psychological healing. It is used in combination with other therapeutic approaches to help treat depression, anxiety, PTSD and CPTSD.
How does it work?
Ketamine has unique neurochemical effects that distinguish it from traditional antidepressants. It primarily works by modulating the brain’s glutamate system, particularly the NMDA receptors, leading to rapid neuroplastic changes—essentially helping the brain form new connections much more quickly than is possible in an ordinary state of consciousness. This can provide a “reset” for nervous systems that have been stuck in chronic fight, flight or freeze as a result of trauma or chronic stress.
During a KAT session, clients are administered ketamine in a clinical setting (typically via intramuscular injection or oral lozenge), accompanied by psychotherapy. The altered state induced by ketamine can enhance introspection, reduce psychological defenses, and allow deeper access to subconscious material. The presence of a trained therapist ensures that insights from the experience are explored, integrated, and used constructively.
Who is it for?
KAT is primarily recommended for individuals with treatment-resistant mental health conditions—those who have tried other approaches but still find themselves stuck in old patterns. This includes: Major depressive disorder, PTSD and CPTSD, chronic suicidal ideation and existential distress.
Not everyone is a candidate for KAT. It is not typically recommended for individuals with a history of psychosis, uncontrolled hypertension, or certain cardiovascular conditions.
References:
Active mechanisms of ketamine-assisted psychotherapy: A systematic review
Ketamine-Assisted Psychotherapy for PTSD Related to Racial Discrimination